Typically, treatment is assigned in a nonadaptive manner, where assignments are determined before any outcomes are observed.

We study the design of adaptive, sequential experiments for unbiased average treatment effect (ATE) estimation in the design-based potential outcomes setting. Our goal is to develop adaptive designs offering sublinear Neyman regret, meaning their efficiency must approach that of the hindsight-optimal nonadaptive design. Recent work [Dai et al, 2023] introduced ClipOGD, the first method achieving $\widetilde{O}(\sqrt{T})$ expected Neyman regret under mild conditions. In this work, we propose adaptive designs with substantially stronger Neyman regret guarantees. In particular, we modify ClipOGD to obtain anytime $\widetilde{O}(\log T)$ Neyman regret under natural boundedness assumptions. Further, in the setting where experimental units have pre-treatment covariates, we introduce and study a class of contextual "multigroup" Neyman regret guarantees: Given any set of possibly overlapping groups based on the covariates, the adaptive design outperforms each group's best non-adaptive designs. In particular, we develop a contextual adaptive design with $\widetilde{O}(\sqrt{T})$ anytime multigroup Neyman regret. We empirically validate the proposed designs through an array of experiments.

Estimation and inference for the Average Treatment Effect (ATE) is a cornerstone of causal inference and often serves as the foundation for developing procedures for more complicated settings. Although traditionally analyzed in a batch setting, recent advances in martingale theory have paved the way for adaptive methods that can enhance the power of downstream inference. Despite these advances, progress in understanding and developing adaptive algorithms remains in its early stages. Existing work either focus on asymptotic analyses that overlook exploration-exploitation tradeoffs relevant in finite-sample regimes or rely on simpler but suboptimal estimators. In this work, we address these limitations by studying adaptive sampling procedures that take advantage of the asymptotically optimal Augmented Inverse Probability Weighting (AIPW) estimator. Our analysis uncovers challenges obscured by asymptotic approaches and introduces a novel algorithmic design principle reminiscent of optimism in multiarmed bandits. This principled approach enables our algorithm to achieve significant theoretical and empirical gains compared to prior methods. Our findings mark a step forward in advancing adaptive causal inference methods in theory and practice.

Estimation of the Average Treatment Effect (ATE) is a core problem in causal inference with strong connections to Off-Policy Evaluation in Reinforcement Learning. This paper considers the problem of adaptively selecting the treatment allocation probability in order to improve estimation of the ATE. The majority of prior work on adaptive ATE estimation focus on asymptotic guarantees, and in turn overlooks important practical considerations such as the difficulty of learning the optimal treatment allocation as well as hyper-parameter selection. Existing non-asymptotic methods are limited by poor empirical performance and exponential scaling of the Neyman regret with respect to problem parameters. In order to address these gaps, we propose and analyze the Clipped Second Moment Tracking (ClipSMT) algorithm, a variant of an existing algorithm with strong asymptotic optimality guarantees, and provide finite sample bounds on its Neyman regret. Our analysis shows that ClipSMT achieves exponential improvements in Neyman regret on two fronts: improving the dependence on $T$ from $O(\sqrt{T})$ to $O(\log T)$, as well as reducing the exponential dependence on problem parameters to a polynomial dependence. Finally, we conclude with simulations which show the marked improvement of ClipSMT over existing approaches.